80 research outputs found
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
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- Wulandari R.
- Wyllie D. H.
- Wynter I.
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- Xue X.
- Yadav A.
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- Yates B.
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- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A. C.
- Zeberg H.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Get PDFCritical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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- Publication venue
- 'Society of Exploration Geophysicists'
- Publication date
- Field of study
No full textThigh-length compression stockings and DVT after stroke
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- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
- Abdul B
- Abdulmumeen A
- Abdulshukkoor N
- Abdusamad K
- Aboaba A
- Abouibrahim M
- Abraham M
- Abraham T
- Abrams J
- Abung A
- Acharya D
- Acharya D
- Acheson J
- Acosta A
- Acosta A
- Acton C
- Adam M
- Adams C
- Adams K
- Adamus M
- Adegoke K
- Adenwalla S
- Adeyeye E
- Adnan A
- Agbo C
- Aggarwal S
- Agwada-Akeru J
- Agyapong K Ansu
- Ah-Chuen J
- Ahmad M
- Ahmed I
- Ahmed I
- Ahmed L
- Ahmed L
- Ahmed M
- Ahmed M Cecilia
- Ahmed N
- Ahmed N
- Ahmed R
- Ahmed RA
- Ahmed S
- Ahmed S Haris
- Ail D
- Ainsley A
- Ainsworth M
- Aitken L
- Ajibode A
- Ajmi A
- Ajmi A
- Akhtar N
- Akili S
- Akindolie O
- Al Balushi A
- Al-Asadi A
- Al-Hakim B
- Al-Jibury M
- Al-Rabahi A
- Al-Ramadhani B
- Al-Shamkhani W
- Al-Sheklly B
- Alam S
- Aldana A
- Aldouri R
- Aldridge N
- Alegria A
- Alexander A
- Alexander J
- Alexander PDG
- Ali F Runa
- Ali M
- Ali O
- Ali S
- Ali S
- Ali S
- Alkhusheh M
- Alkhusheh M
- Allanson A
- Allen L
- Allen R
- Allen S
- Allison K
- Allsop L
- Alomari L
- Alzetani M
- Ambler S
- Ambrogetti R
- Ambrose C
- Amezaga M
- Amin A
- Amosun V
- Amosun V
- Amsha K
- Anand A
- Anderson J
- Anderson L
- Anderson N
- Anderson R
- Andreou P
- Andrews A
- Andrews J
- Aneke K
- Ang A
- Angel T
- Antill P
- Antonina Z
- Anu V
- Appleby S
- Appleyard D
- Archer A
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- Arora D
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- Asghar A
- Ashbrook-Raby C
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- Ashton D
- Asrar A
- Assaf O
- Astin-Chamberlain R
- Athorne D
- Atkinson J
- Atkinson V
- Aubrey P
- Aung K Thu
- Aung N
- Aung Z Myo
- Austin E
- Avery M
- Avram C
- Awadzi G
- Aya A
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- Aziz G
- Azzopardi G
- Babatunde F
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Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
The Australian arthritis and autoimmune biobank collabortive (A3BC) protocol
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
No full textTHE AUSTRALIAN CASE FOR PROTECTION RECONSIDERED
- Author
- American Economic Association
- Anderson K.
- Anderson K.
- Benham F. C.
- Benham F. C.
- Benham F. C.
- Bhagwati J.
- Brigden J. B.
- Brigden J. B.
- Brigden J. B.
- Brigden J. B.
- Brigden J. B.
- Cain N.
- Caves R. E.
- Copland D. B.
- Copland D. B.
- Copland D. B.
- Copland D. B.
- Corden W. M.
- Corden W. M.
- Ellis H. S.
- Giblin L. F.
- James D. E.
- Kaldor N.
- Kemp M. C.
- Metzler L. A.
- Ohlin B.
- Patten S. N.
- Pigou A. C.
- Reddaway W. B.
- Reddaway W. B.
- Reitsma A. J.
- Reitsma A. J.
- Ricardo D.
- Samuelson M. C.
- Samuelson P. A.
- Schueller R.
- Staley C. E.
- Stiglitz J. E.
- Stolper W. F.
- Taussig F. W.
- Viner J.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textUsing a complex adaptive system lens to understand family caregiving experiences navigating the stroke rehabilitation system
- Author
- AL Silva-Smith
- Andrea Ghazzawi
- B Ellis
- B Lutz
- C Cott
- C Ellis-Hill
- C Geary
- Craig Kuziemsky
- DB Weinberg
- DT Liss
- E Carlsson
- E Coiera
- E Coleman
- F Griffiths
- G Worrall
- I Jones
- J Cameron
- J Grant
- J Haggerty
- JP Sturmberg
- K Byrne
- L Edgren
- M Benham-Hutchins
- M Boulton
- M Burman
- M Cree
- M Gulliford
- M King
- N Aziz
- N Greenwood
- R Adler
- R Ionescu-Ittu
- R King
- R Teasell
- S Cheng
- T Clancy
- T Kannampallil
- Tracey O’Sullivan
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textGreasing the Wheels of Trade
- Author
- A B Krueger
- A Benham
- A Burger
- A F Ades
- A Greif
- A Johri
- A K Dixit
- A K Dixit
- A M Mayda
- A Rubinstein
- Adam Smith
- Aico van Vuuren
- C S Boerner
- C Van Eijl
- D A Irwin
- D C North
- D C North
- D F Spulber
- D Landes
- D Trefler
- E E Leamer
- E Schulte Nordholt
- G Ellison
- Hendrik P. van Dalen
- J De Vries
- J E Rauch
- J I Israel
- J J Heckman
- J J Heckman
- J J Wallis
- J Jonker
- J L Van Zanden
- J L Van Zanden
- J Niehans
- J Oosterhaven
- J T Landa
- K J Arrow
- L E Davis
- M Casson
- M Fujita
- M P Keane
- O E Williamson
- O E Williamson
- P D Curtin
- P Ellis
- P Ellis
- P Ellis
- P J Katzenstein
- R C Feenstra
- R H Coase
- R J Caballero
- R Mahadevan
- W H Greene
- W Sombart
- Y Barzel
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
No full textIllusory colors promote interocular grouping during binocular rivalry
- Author
- A. Gorea
- A. Treisman
- B. Laeng
- B. Pinna
- C. -Y. Kim
- C. -Y. Kim
- C. E. Benham
- C. F. Stromeyer
- C. McCollough
- Chai-Youn Kim
- D. Alais
- E. Gyulai
- G. K. Humphrey
- H. E. M. Ouden Den
- H. Wallach
- I. Kovács
- J. J. Kulikowski
- J. Krauskopf
- J. R. Jordan
- K. D. White
- L. A. Riggs
- M. Green
- M. Wertheimer
- P. D. Jones
- P. Thompson
- R. Blake
- Randolph Blake
- S. R. Ellis
- T. J. Andrews
- T. J. Palmeri
- T. V. Papathomas
- V. S. Ramachandran
- V. S. Ramachandran
- W. Byth
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textUK Environmental Change Network (ECN) fine grain vegetation data: 1994-2015
- Author
- Adamson J.
- Anderson R.
- Andrews C.
- Bater J.
- Bayfield N.
- Beaton K.
- Beaumont D. A.
- Benham S.
- Bowmaker V.
- Britt C.
- Brooker R.
- Brooks D. R.
- Brunt J.
- Common G.
- Cooper R.
- Corbett S.
- Critchley N.
- Dennis P.
- Dick J.
- Dodd B.
- Dodd N.
- Donovan N.
- Easter J.
- Flexen M.
- Gardiner A.
- Hamilton D.
- Hargreaves P.
- Hatton-Ellis M.
- Howe M.
- Kahl J.
- Lane M.
- Langan S.
- Lloyd D.
- McElarney Y.
- McKenna C.
- McMillan S.
- Milne F.
- Milne L.
- Morecroft M.
- Murphy M.
- Nelson A.
- Nicholson H.
- Pallett D.
- Parry D.
- Pearce I.
- Pozsgai G.
- Rennie S.
- Rose R.
- Schafer S.
- Scott T.
- Sherrin L.
- Shortall C. R.
- Smith P.
- Smith R. I.
- Tait R.
- Taylor C.
- Taylor M.
- Thurlow M.
- Tilbury C.
- Turner A.
- Tyson K.
- Watson H.
- Whittaker M.
- Wood C.
- Publication venue
- Centre for Ecology and Hydrology (CEH)
- Publication date
- 01/01/2017
- Field of study
No full textFine Grain Vegetation data from the UK Environmental Change Network (ECN) terrestrial sites. These data are collected at all of ECN's terrestrial sites using a standard protocol (see supporting documentation). In this protocol, 10m x 10m plots are randomly selected within each vegetation type on the site - species presence is recorded in 40cm x 40 cm cells randomly selected within these plots. They represent continuous records every three years (some sites record data annually) from 1994 to 2015. ECN is the UK\u92s long-term environmental monitoring programme. It is a multi-agency programme sponsored by a consortium of fourteen government departments and agencies. These organisations contribute to the programme through funding either site monitoring and/or network co-ordination activities. These organisations are: Agri-Food and Biosciences Institute, Biotechnology and Biological Sciences Research Council, Cyfoeth Naturiol Cymru - Natural Resources Wales, Defence Science & Technology Laboratory, Department for Environment, Food and Rural Affairs, Environment Agency, Forestry Commission, Llywodraeth Cymru - Welsh Government, Natural England, Natural Environment Research Council, Northern Ireland Environment Agency, Scottish Environment Protection Agency, Scottish Government and Scottish Natural Heritage
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